Hirata JD, Swiersz LM, Zell B, et al. The prodrugs 128 and 130 (of 127 and 129, respectively) further exemplify the utility of amino acid prodrugs targeted to transporters other than oligopeptide transporters expressed in the gastrointestinal tract [ 4]. Hyoscyamine: (Moderate) Diphenoxylate is a synthetic opiate derivative that appears to exert its effect locally and centrally on the smooth mucle cells of the GI tract to inhibit GI motility and slow excess GI propulsion www.sayadlia24.com. Iloprost: (Moderate) Iloprost may potentiate the hypotension seen with aldesleukin, IL 2.
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